منابع مشابه
RSK and MSK in MAP kinase signalling.
RSK [for 90 kDa ribosomal S6 kinase (p90rsk); also known as MAPKAP-K1] and MSK (for mitogenand stressactivated protein kinase) constitute a family of protein kinases that mediate signal transduction downstream of MAP kinase cascades. RSK is activated by MAP kinases of the extracellular signalregulated kinase (ERK) family in response to growth factors, many polypeptide hormones, neurotransmitter...
متن کاملCALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
Calcium homeostasis modulator 1 (CALHM1) is a Ca(2+) channel controlling neuronal excitability and potentially involved in the pathogenesis of Alzheimer's disease (AD). Although strong evidence indicates that CALHM1 is required for neuronal electrical activity, its role in intracellular Ca(2+) signaling remains unknown. In the present study, we show that in hippocampal HT-22 cells, CALHM1 expre...
متن کاملEmerging MAP kinase pathways in plant stress signalling.
Mitogen-activated protein kinase (MAPK) pathways transfer information from sensors to cellular responses in all eukaryotes. A surprisingly large number of genes encoding MAPK pathway components have been uncovered by analysing model plant genomes, suggesting that MAPK cascades are abundant players of signal transduction. Recent investigations have confirmed major roles of defined MAPK pathways ...
متن کاملCALHM 1 controls Ca 2 + - dependent MEK / ERK / RSK / MSK signaling in
CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in 1 neurons 2 3 Ute Dreses-Werringloer, Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Peter 4 Davies, Philippe Marambaud 5 6 Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for 7 Medical Research, Manhasset, New York, USA. Department of Pathology, Albert Einstein 8 College of M...
متن کاملInhibition of ERK-MAP kinase signaling by RSK during Drosophila development.
Although p90 ribosomal S6 kinase (RSK) is known as an important downstream effector of the ribosomal protein S6 kinase/extracellular signal-regulated kinase (Ras/ERK) pathway, its endogenous role, and precise molecular function remain unclear. Using gain-of-function and null mutants of RSK, its physiological role was successfully characterized in Drosophila. Surprisingly, RSK-null mutants were ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2006
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02950